Indiana Cohort Enhancement Study (4K Hoosiers)

The Indiana Cohort Enhancement Study, nicknamed the 4K Hoosiers Study, will recruit a cohort of 4,000 individuals throughout Indiana, especially from underrepresented groups, to evaluate the influence of geographic, socioeconomic and physiological factors related to morbidity, utilization, and outcomes of the PHI. Within this study, the Network Embedded Symbiome framework offers a unifying mechanism of action. Health, disease and risk behaviors are conceptualized as a bio-psycho-social process managed by social networks in the community and in treatment systems. Network ties serve as the mechanism linking influences within and across societal levels. This cohort will provide unique data necessary for understanding psychosocial and behavioral factors in precision health and medicine, especially focused on chronic illness. The study supports all four focal challenges.